Patient-derived heavy chain antibody targets cell surface HSP90 on breast tumors

Heavy and Light Chain Allotypic Markers on Rabbit Homocytotropic Antibody

Evidence has been presented that rabbit homocytotropic antibody prepared against ovalbumin bears allotypic markers of both group a (heavy chain) and group b (light chain). This was shown by specific removal of activity in passive cutaneous anaphylaxis assays by anti-allotype immunoadsorbents. The homocytotropic antibody has properties which indicate that it belongs to a new class of rabbit immu...

Monoclonal antibody 8H9 targets a novel cell surface antigen expressed by a wide spectrum of human solid tumors.

Tumor-restricted surface antigens may be targets for diagnosis and immune-based therapies. Monoclonal antibody 8H9 is a murine IgG1 hybridoma derived from the fusion of mouse myeloma SP2/0 cells and splenic lymphocytes from BALB/c mice immunized with human neuroblastoma. By immunohistochemistry, 8H9 was highly reactive with human brain tumors, childhood sarcomas, and neuroblastomas, and less so...

Multiple heavy chain isotypes on the surface of the cells of hairy cell leukemia.

A series of 15 patients with hairy-cell leukemia was studied for SI9. Mononuclear cells isolated from peripheral blood (15), spleen (6), bone marrow (2), and lymph node (1) were tested for SIg by a sensitive rosette method, and extensive precautions were taken to avoid the various problems causing nonintrinsic Ig binding and to ensure the specificity of the antisera. Slg of restricted light cha...

Preparation of heavy chain polyclonal antibody against zinc transporter SLC39A6 and its diagnostic application

Background: SLC39A6 Protein (solute carrier family 39) or LIV-1 is a zinc transporter protein that is overexpressed in positive estrogen cancers such as breast cancer. The LIV-1 protein transfer zinc into the cytoplasm through the plasma membrane. Today it is known that just as a decrease in the concentration of zinc in the cell can cause cancer, an excessive increase in the concentration of zi...

Vibsanin B Preferentially Targets HSP90